{"id":3290,"date":"2023-08-14T22:41:36","date_gmt":"2023-08-14T14:41:36","guid":{"rendered":"https:\/\/elephantalkshow.com\/?p=3290"},"modified":"2023-08-14T22:41:39","modified_gmt":"2023-08-14T14:41:39","slug":"%e6%96%b0%e7%9a%84%e5%a4%9a%e5%9b%8a%e6%82%a3%e8%80%85%e4%ba%ba%e6%95%b8%e7%af%80%e7%af%80%e4%b8%8a%e5%8d%87%e4%b8%ad%ef%bc%8c%e8%80%8c%e6%88%91%e5%80%91%e6%96%b0%e7%9a%84%e5%b1%95%e6%9c%9b%e6%98%af","status":"publish","type":"post","link":"https:\/\/elephantalkshow.com\/%e6%96%b0%e7%9a%84%e5%a4%9a%e5%9b%8a%e6%82%a3%e8%80%85%e4%ba%ba%e6%95%b8%e7%af%80%e7%af%80%e4%b8%8a%e5%8d%87%e4%b8%ad%ef%bc%8c%e8%80%8c%e6%88%91%e5%80%91%e6%96%b0%e7%9a%84%e5%b1%95%e6%9c%9b%e6%98%af\/","title":{"rendered":"\u65b0\u7684\u591a\u56ca\u60a3\u8005\u4eba\u6578\u7bc0\u7bc0\u4e0a\u5347\u4e2d\uff0c\u800c\u6211\u5011\u65b0\u7684\u5c55\u671b\u662f?"},"content":{"rendered":"\n<p>\u8eab\u70ba\u4e00\u500b\u5728\u5973\u6027\u4e2d\u76db\u884c\u7387\u9ad8\u90546-21%\u7684\u75be\u75c5\uff0c\u6bcf\u5e74\u81f3\u5c11\u90fd\u6709\u8d85\u904e150\u842c\u500b\u65b0\u8a3a\u65b7\u51fa\u4f86\u7684\u591a\u56ca\u60a3\u8005\uff0c\u800c\u4e14\u65b0\u7684\u8a3a\u65b7\u6709\u9010\u6f38\u5e74\u8f15\u5316\u7684\u8da8\u52e2\uff0c\u5176\u4e2d\u670917%\u4ee5\u4e0a\u90fd\u662f\u4ecb\u65bc21-30\u6b72\u3002\u73fe\u5728\u7684\u89c0\u5ff5\u5df2\u7d93\u8a8d\u70ba\u591a\u56ca\u6027\u5375\u5de2\u662f\u4ee3\u8b1d\u6027\u7684\u75be\u75c5\uff1a<\/p>\n\n\n\n<p class=\"has-vivid-red-color has-text-color has-medium-font-size\">50%\u7684\u60a3\u8005\u6709\u9ad4\u91cd\u904e\u91cd\u7684\u554f\u984c<\/p>\n\n\n\n<p class=\"has-vivid-red-color has-text-color has-medium-font-size\">30%\u7684\u60a3\u8005\u8840\u7cd6\u6703\u51fa\u73fe\u7570\u5e38<\/p>\n\n\n\n<p class=\"has-vivid-red-color has-text-color has-medium-font-size\">7.5%\u7684\u60a3\u8005\u5df2\u7d93\u7f79\u60a3\u6709\u7cd6\u5c3f\u75c5<\/p>\n\n\n\n<p>\u9019\u4e9b\u4f75\u6709\u9ad4\u91cd\u904e\u91cd\u3001\u80a5\u80d6\u554f\u984c\u7684\u591a\u56ca\u60a3\u8005\uff0c\u8ddf\u9ad4\u91cd\u4ecb\u65bc\u6b63\u5e38\u503c\uff0c\u4fd7\u7a31\u7626\u591a\u56ca\u7684\u60a3\u8005\u6bd4\u8d77\u4f86\uff0c\u80d6\u591a\u56ca\u6709\u8f03\u9ad8\u7684\u6bd4\u4f8b\u6703\u51fa\u73fe\u300c\u4ee3\u8b1d\u75c7\u5019\u7fa4\u300d(\u80d6\u591a\u56ca47.9%\u3001\u7626\u591a\u56ca15.9%)\uff0c\u800c\u4ee5\u300c\u80f0\u5cf6\u7d20\u963b\u6297\u6027\u300d\u4f86\u8aaa\uff0c\u80d6\u591a\u56ca\u670927.8%\u7684\u6a5f\u6703\u6703\u6709\uff1b\u7626\u591a\u56ca\u5247\u662f\u53ea\u67097.1%\u3002\u5927\u8c61\u91ab\u5e2b\u63d0\u9192\uff0c\u5176\u5be6\u5c31\u7b97\u6c92\u6709\u591a\u56ca\u6027\u5375\u5de2\uff0c\u80a5\u80d6\u672c\u8eab\u6240\u5e36\u4f86\u904e\u591a\u7684\u8102\u80aa\u7d30\u80de\uff0c\u672c\u4f86\u5c31\u6703\u589e\u52a0\u80f0\u5cf6\u7d20\u4ee3\u8b1d\u7684\u7570\u5e38\u3002<\/p>\n\n\n\n<p>\u9019\u4e9b\u4ee3\u8b1d\u6027\u7684\u554f\u984c\uff0c\u5176\u5be6\u6703\u8ddf\u8457\u591a\u56ca\u60a3\u8005\u4e00\u8f29\u5b50\uff0c\u5728\u80b2\u9f61\u6642\u671f\u9664\u4e86\u4e0d\u5b55\u3001\u598a\u5a20\u7cd6\u5c3f\u75c5\u4e4b\u5916\uff0c\u5230\u4e2d\u8001\u5e74\u4e5f\u6703\u7e7c\u7e8c\u5e36\u4f86\u7cd6\u5c3f\u75c5\u3001\u4e2d\u98a8\u8ddf\u5fc3\u8840\u7ba1\u751a\u81f3\u764c\u75c7\u7684\u98a8\u96aa\u589e\u52a0\u3002\u4f46\u5c31\u5982\u540c\u6211\u5011\u73fe\u5728\u80fd\u6b63\u5e38\u770b\u5f85\u9ad8\u8840\u58d3\u4e00\u822c\uff0c\u591a\u56ca\u6027\u5375\u5de2\u61c9\u8a72\u88ab\u8996\u70ba\u4e00\u500b\u53ef\u4ee5\u9577\u671f\u63a7\u5236\u826f\u597d\u7684\u75be\u75c5\u3002<\/p>\n\n\n\n<div 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title=\"\u591a\u56ca\u6027\u5375\u5de2\u7684\u6210\u56e0\">\u591a\u56ca\u6027\u5375\u5de2\u7684\u6210\u56e0<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/elephantalkshow.com\/%e6%96%b0%e7%9a%84%e5%a4%9a%e5%9b%8a%e6%82%a3%e8%80%85%e4%ba%ba%e6%95%b8%e7%af%80%e7%af%80%e4%b8%8a%e5%8d%87%e4%b8%ad%ef%bc%8c%e8%80%8c%e6%88%91%e5%80%91%e6%96%b0%e7%9a%84%e5%b1%95%e6%9c%9b%e6%98%af\/#1_%E9%81%BA%E5%82%B3%E8%AE%8A%E7%95%B0Genetic_variants\" title=\"1. \u907a\u50b3\u8b8a\u7570(Genetic variants)\">1. \u907a\u50b3\u8b8a\u7570(Genetic variants)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/elephantalkshow.com\/%e6%96%b0%e7%9a%84%e5%a4%9a%e5%9b%8a%e6%82%a3%e8%80%85%e4%ba%ba%e6%95%b8%e7%af%80%e7%af%80%e4%b8%8a%e5%8d%87%e4%b8%ad%ef%bc%8c%e8%80%8c%e6%88%91%e5%80%91%e6%96%b0%e7%9a%84%e5%b1%95%e6%9c%9b%e6%98%af\/#2_%E8%A1%A8%E8%A7%80%E9%81%BA%E5%82%B3%E5%AD%B8DNA_methylation_in_Epigenetics\" title=\"2. \u8868\u89c0\u907a\u50b3\u5b78(DNA methylation in Epigenetics)\">2. \u8868\u89c0\u907a\u50b3\u5b78(DNA methylation in Epigenetics)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/elephantalkshow.com\/%e6%96%b0%e7%9a%84%e5%a4%9a%e5%9b%8a%e6%82%a3%e8%80%85%e4%ba%ba%e6%95%b8%e7%af%80%e7%af%80%e4%b8%8a%e5%8d%87%e4%b8%ad%ef%bc%8c%e8%80%8c%e6%88%91%e5%80%91%e6%96%b0%e7%9a%84%e5%b1%95%e6%9c%9b%e6%98%af\/#3_%E8%85%B8%E8%83%83%E9%81%93%E8%8F%8C%E5%8F%A2%E8%88%87%E8%85%A6%E8%85%B8%E8%BB%B8Gut_Microbiota_Alternation_and_Brain-Gut_Axis\" title=\"3. \u8178\u80c3\u9053\u83cc\u53e2\u8207\u8166\u8178\u8ef8(Gut Microbiota Alternation and Brain-Gut Axis)\">3. \u8178\u80c3\u9053\u83cc\u53e2\u8207\u8166\u8178\u8ef8(Gut Microbiota Alternation and Brain-Gut Axis)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/elephantalkshow.com\/%e6%96%b0%e7%9a%84%e5%a4%9a%e5%9b%8a%e6%82%a3%e8%80%85%e4%ba%ba%e6%95%b8%e7%af%80%e7%af%80%e4%b8%8a%e5%8d%87%e4%b8%ad%ef%bc%8c%e8%80%8c%e6%88%91%e5%80%91%e6%96%b0%e7%9a%84%e5%b1%95%e6%9c%9b%e6%98%af\/#4_%E5%A4%A7%E8%85%A6%E9%82%8A%E7%B7%A3%E7%B3%BB%E7%B5%B1%E5%8F%8D%E6%87%89Corticolimbic_Brain_Response\" title=\"4. \u5927\u8166\u908a\u7de3\u7cfb\u7d71\u53cd\u61c9(Corticolimbic Brain Response)\">4. \u5927\u8166\u908a\u7de3\u7cfb\u7d71\u53cd\u61c9(Corticolimbic Brain Response)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/elephantalkshow.com\/%e6%96%b0%e7%9a%84%e5%a4%9a%e5%9b%8a%e6%82%a3%e8%80%85%e4%ba%ba%e6%95%b8%e7%af%80%e7%af%80%e4%b8%8a%e5%8d%87%e4%b8%ad%ef%bc%8c%e8%80%8c%e6%88%91%e5%80%91%e6%96%b0%e7%9a%84%e5%b1%95%e6%9c%9b%e6%98%af\/#5_%E4%BB%A3%E8%AC%9D%E9%AB%94%E5%AD%B8Metabolome_Changes\" title=\"5. \u4ee3\u8b1d\u9ad4\u5b78(Metabolome Changes)\">5. \u4ee3\u8b1d\u9ad4\u5b78(Metabolome Changes)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/elephantalkshow.com\/%e6%96%b0%e7%9a%84%e5%a4%9a%e5%9b%8a%e6%82%a3%e8%80%85%e4%ba%ba%e6%95%b8%e7%af%80%e7%af%80%e4%b8%8a%e5%8d%87%e4%b8%ad%ef%bc%8c%e8%80%8c%e6%88%91%e5%80%91%e6%96%b0%e7%9a%84%e5%b1%95%e6%9c%9b%e6%98%af\/#%E5%A4%9A%E5%9B%8A%E6%80%A7%E5%8D%B5%E5%B7%A2%E7%9A%84%E6%B2%BB%E7%99%82\" title=\"\u591a\u56ca\u6027\u5375\u5de2\u7684\u6cbb\u7642\">\u591a\u56ca\u6027\u5375\u5de2\u7684\u6cbb\u7642<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a 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ez-toc-heading-10\" href=\"https:\/\/elephantalkshow.com\/%e6%96%b0%e7%9a%84%e5%a4%9a%e5%9b%8a%e6%82%a3%e8%80%85%e4%ba%ba%e6%95%b8%e7%af%80%e7%af%80%e4%b8%8a%e5%8d%87%e4%b8%ad%ef%bc%8c%e8%80%8c%e6%88%91%e5%80%91%e6%96%b0%e7%9a%84%e5%b1%95%e6%9c%9b%e6%98%af\/#Reference\" title=\"Reference\">Reference<\/a><\/li><\/ul><\/nav><\/div>\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%A4%9A%E5%9B%8A%E6%80%A7%E5%8D%B5%E5%B7%A2%E7%9A%84%E6%88%90%E5%9B%A0\"><\/span>\u591a\u56ca\u6027\u5375\u5de2\u7684\u6210\u56e0<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img fetchpriority=\"high\" decoding=\"async\" src=\"https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/08\/image.png\" alt=\"\u591a\u56ca\u6027\u5375\u5de2\u7684\u4e94\u5927\u9762\u5411\" class=\"wp-image-3291\" style=\"object-fit:cover;width:500px;height:500px\" width=\"500\" height=\"500\" srcset=\"https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/08\/image.png 844w, https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/08\/image-300x300.png 300w, https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/08\/image-150x150.png 150w, https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/08\/image-768x766.png 768w, https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/08\/image-600x599.png 600w, https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/08\/image-100x100.png 100w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/figure>\n\n\n\n<p>\u96a8\u8457\u9019\u4e9b\u5e74\u4f86\u7684\u5206\u5b50\u751f\u7269\u79d1\u6280\u3001\u57fa\u56e0\u7be9\u6aa2\u80b2\u52a0\u767c\u9054\uff0c\u5c0d\u65bc\u591a\u56ca\u7684\u7406\u89e3\u5176\u5be6\u4e5f\u5df2\u7d93\u66f4\u900f\u5fb9\u4e86\u3002\u4e0d\u53ea\u662f\u57fa\u56e0\u3001\u66f4\u662f\u8868\u89c0\u907a\u50b3\u5b78\u3001\u8178\u80c3\u9053\u83cc\u53e2\u8ddf\u8166\u888b\u7684\u908a\u7de3\u7cfb\u7d71\u7b49\u5168\u9762\u7684\u7814\u7a76\uff0c\u5982\u540c\u5075\u63a2\u4e00\u822c\uff0c\u7a2e\u7a2e\u7684\u7dda\u7d22\u9010\u6b65\u4ea4\u932f\u5728\u4e00\u584a\uff0c\u591a\u56ca\u7684\u5168\u5c40\u8108\u7d61\uff0c\u4f3c\u4e4e\u4e5f\u66f4\u6e05\u6670\u4e86\u4e00\u4e9b\u3002<\/p>\n\n\n\n<p>\u63a5\u4e0b\u4f86\u6211\u5011\u6703\u5c31\u5404\u500b\u9762\u5411\u4f86\u4f5c\u63a2\u8a0e\uff1a<\/p>\n\n\n\n<p class=\"has-ast-global-color-0-color has-text-color has-medium-font-size\"><strong>\u907a\u50b3\u8b8a\u7570(Genetic variants)<\/strong><\/p>\n\n\n\n<p class=\"has-ast-global-color-0-color has-text-color has-medium-font-size\"><strong>\u8868\u89c0\u907a\u50b3\u5b78(DNA methylation in Epigenetics)<\/strong><\/p>\n\n\n\n<p class=\"has-ast-global-color-0-color has-text-color has-medium-font-size\"><strong>\u8178\u80c3\u9053\u83cc\u53e2\u8207\u8166\u8178\u8ef8(Gut Microbiota Alternation and Brain-Gut Axis)<\/strong><\/p>\n\n\n\n<p class=\"has-ast-global-color-0-color has-text-color has-medium-font-size\"><strong>\u5927\u8166\u908a\u7de3\u7cfb\u7d71\u53cd\u61c9(Corticolimbic Brain Response)<\/strong><\/p>\n\n\n\n<p class=\"has-ast-global-color-0-color has-text-color has-medium-font-size\"><strong>\u4ee3\u8b1d\u9ad4\u5b78(Metabolome Changes)<\/strong><\/p>\n\n\n\n<p><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"1_%E9%81%BA%E5%82%B3%E8%AE%8A%E7%95%B0Genetic_variants\"><\/span><strong>1. \u907a\u50b3\u8b8a\u7570(Genetic variants)<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u8fd1\u5e74\u4f86\u9032\u5c55\u6700\u5927\u7684\u79d1\u6280\u4e2d\uff0c\u57fa\u56e0\u5927\u898f\u6a21\u5b9a\u5e8f\u7d55\u5c0d\u6709\u4e00\u5e2d\u4e4b\u5730\uff0c\u5728\u91dd\u5c0d\u6f22\u65cf\u7fa4\u505a\u4e86\u5168\u57fa\u56e0\u7d44\u95dc\u806f\u5206\u6790\uff08genome-wide association study\uff0c\u7c21\u7a31GWAS \uff09\u4e4b\u5f8c\u767c\u73fe\uff0c\u50cf\u662fTHADA\u3001LHCGR\u3001DENND1A\u3001HNGA2\u3001TOX3\u3001FSHR\u7b49\u773e\u591a\u57fa\u56e0\u90fd\u8ddf\u591a\u56ca\u6027\u5375\u5de2\u6709\u95dc\u3002\u50cf\u662fDENND1A\u3001TOX3\u6703\u8ddf\u80f0\u5cf6\u7d20\u963b\u6297\u6709\u95dc\u800cTHADA\u3001INSR\u5247\u8ddf\u4ee3\u8b1d\u75c7\u5019\u7fa4\u6709\u95dc\u3002\u800c\u4e14\u79d1\u5b78\u5bb6\u5011\u9084\u767c\u73fe\u5176\u5be6\u591a\u56ca\u8ddf\u7b2c\u4e8c\u578b\u7cd6\u5c3f\u75c5\u5171\u4eab\u4e86\u5f88\u591a\u76f8\u540c\u7684\u7570\u5e38\u57fa\u56e0\u8868\u73fe\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2_%E8%A1%A8%E8%A7%80%E9%81%BA%E5%82%B3%E5%AD%B8DNA_methylation_in_Epigenetics\"><\/span><strong>2. \u8868\u89c0\u907a\u50b3\u5b78(DNA methylation in Epigenetics)<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u96d6\u7136\u4e0d\u5c11\u591a\u56ca\u7684\u60a3\u8005\u767c\u73fe\u7f79\u75c5\u7684\u6a5f\u7387\u8207\u89aa\u5c6c\u95dc\u806f\u6709\u95dc\u4fc2\uff0c\u4f46\u5c31GWAS\u4f86\u770b\u5176\u5be6\u771f\u6b63\u7684\u907a\u50b3\u6027\u4e0d\u523010%\u3002\u9019\u6697\u793a\u4e86\u4e00\u500b\u91cd\u8981\u7684\u7dda\u7d22\uff0c\u90a3\u5c31\u662f\u74b0\u5883\u8ddf\u8868\u89c0\u907a\u50b3\u5728\u591a\u56ca\u4e2d\u4f54\u4e86\u91cd\u8981\u7684\u9762\u5411\u3002<\/p>\n\n\n\n<p>\u8868\u89c0\u907a\u50b3\u5305\u542b\u4e86\u300c\u8f03\u5dee\u7684\u5b50\u5bae\u5167\u74b0\u5883\u300d\u8ddf\u300c\u65b0\u751f\u5152\u74b0\u5883\u300d\u3002\u6709\u5b78\u8005\u5c31\u5229\u7528RNA\u7684\u5b9a\u5e8f\u767c\u73fe\u8aaa\u300cDNA\u7684\u4f4e\u7532\u57fa\u5316(DNA hypomethylation)\u300d\u8ddf\u9020\u6210\u6162\u6027\u767c\u708e\u3001\u80f0\u5cf6\u7d20\u8a0a\u865f\u50b3\u905e\u8ddf\u8461\u8404\u7cd6\u4ee3\u8b1d\u5927\u6709\u5e72\u4fc2\u3002<\/p>\n\n\n\n<p>\u9019\u88e1\u6574\u6bb5\u8a71\u7684\u610f\u601d\u662f\u6307\u8aaa\uff0c\u65e9\u9ede\u767c\u73fe\u591a\u56ca\u7684\u8a3a\u65b7\uff0c\u5728\u6539\u5584\u500b\u4eba\u7684\u96c4\u6027\u7d20\u904e\u9ad8(Hyperandrogenism)\u3001\u8abf\u7bc0\u4ee3\u8b1d\u7570\u5e38(Metabolic dysfunction)\u4e4b\u5916\uff0c\u5176\u5be6\u4e5f\u6703\u5e6b\u52a9\u5230\u81ea\u5df1\u7684\u4e0b\u4e00\u4ee3\uff0c\u56e0\u70ba\u81ea\u5df1\u8eab\u4e0a\u7576\u4e0b\u6216\u5f8c\u5929\u9020\u6210\u7684\u554f\u984c\uff0c\u5176\u5be6\u662f\u771f\u7684\u6703\u5f71\u97ff\u5230\u4e0b\u4e00\u4ee3\u7684\uff01\u9019\u4e5f\u662f\u8868\u89c0\u907a\u50b3\u5b78(Epigenetics)\u7684\u6838\u5fc3\u601d\u7dad\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"3_%E8%85%B8%E8%83%83%E9%81%93%E8%8F%8C%E5%8F%A2%E8%88%87%E8%85%A6%E8%85%B8%E8%BB%B8Gut_Microbiota_Alternation_and_Brain-Gut_Axis\"><\/span><strong>3. \u8178\u80c3\u9053\u83cc\u53e2\u8207\u8166\u8178\u8ef8(Gut Microbiota Alternation and Brain-Gut Axis)<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u6709\u5148\u524d\u7684\u7814\u7a76\u6307\u51fa\uff0c\u591a\u56ca\u5973\u5b69\u5176\u5be6\u5c0d\u65bc\u9ad8\u7cd6\u3001\u9ad8\u8102\u80aa\u7684\u98df\u7269\u6709\u8f03\u9ad8\u7684\u504f\u597d\uff0c\u9019\u4e5f\u6703\u9593\u63a5\u5c0e\u81f4\u8178\u9053\u83cc\u53e2\u7684\u7570\u5e38\u3002\u4ee5\u591a\u56ca\u8f03\u5e38\u898b\u7684\u8178\u80c3\u9053\u83cc\u53e2\u4f86\u8aaa\uff0c\u64ec\u687f\u83cc\u79d1\u3001\u7cde\u5e79\u83cc\u7403\u83cc,\u64ec\u687f\u83cc\u5c6c\u3001\u666e\u96f7\u6c83\u6c0f\u83cc\u5c6c\u3001\u4e73\u687f\u83cc\u5c6c\u3001\u526f\u64ec\u687f\u83cc\u5c6c\u3001\u5fd7\u8cc0\u6c0f\u83cc\u5c6c\u548c\u666e\u6c0f\u7cde\u687f\u83cc\u7b49\u8af8\u591a\u83cc\u53e2\u90fd\u6709\u91cd\u8981\u7684\u529f\u80fd\u3002<\/p>\n\n\n\n<p>\u4f46\u662f\u96c4\u6027\u7d20\u904e\u9ad8\u8ddf\u80a5\u80d6\u90fd\u6703\u6e1b\u5c11\u4ee5\u4e0a\u83cc\u53e2\u7684\u591a\u6a23\u6027(Diversity)\uff0c\u9032\u800c\u7834\u58de\u8178\u80c3\u9053\u7684\u9ecf\u819c\u3001\u4fc3\u9032\u4e86\u767c\u708e\u53cd\u61c9\uff0c\u9020\u6210\u5168\u8eab\u7684\u4ee3\u8b1d\u7570\u5e38\u8ddf\u98df\u617e\u904e\u65fa\u7b49\u7b49\u3002\u6709\u7814\u7a76\u63d0\u5230\u8aaa\u76ca\u751f\u5143(Prebiotics)\u80fd\u5920\u6e1b\u5c11\u4e09\u9178\u7518\u6cb9\u8102\u8ddf\u4f4e\u5bc6\u5ea6\u81bd\u56fa\u9187\u7684\u6fc3\u5ea6\uff1b\u800c\u9ad8\u7e96\u7dad\u7684\u98f2\u98df\u4e5f\u80fd\u91cd\u65b0\u8abf\u6574\u8178\u80c3\u9053\u83cc\u53e2\uff0c\u589e\u52a0\u96d9\u6b67\u687f\u83cc(Bifidobacteriu)\u548c\u4e73\u9178\u83cc(Lactobacillus)\uff0c\u800c\u591a\u56ca\u7684\u81e8\u5e8a\u75c7\u72c0\u4e5f\u6703\u56e0\u6b64\u6539\u8b8a\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"4_%E5%A4%A7%E8%85%A6%E9%82%8A%E7%B7%A3%E7%B3%BB%E7%B5%B1%E5%8F%8D%E6%87%89Corticolimbic_Brain_Response\"><\/span><strong>4. \u5927\u8166\u908a\u7de3\u7cfb\u7d71\u53cd\u61c9(Corticolimbic Brain Response)<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u96a8\u8457\u6211\u5011\u5c0d\u5927\u8166\u7684\u908a\u7de3\u7cfb\u7d71\u767c\u5c55\u8d8a\u4f86\u8d8a\u6e05\u695a\uff0c\u6211\u5011\u4e5f\u9010\u6f38\u767c\u73fe\u5230\u591a\u56ca\u7684\u300c\u96c4\u6027\u7d20\u904e\u9ad8\u300d\u8ddf\u300c\u80f0\u5cf6\u7d20\u904e\u9ad8\u300d\u5c0d\u65bc\u4e2d\u6a1e\u7cfb\u7d71\u7684\u5f71\u97ff\u3002\u5148\u524d\u7684\u7814\u7a76\u5c31\u6307\u51fa\uff0c\u591a\u56ca\u60a3\u8005\u56e0\u70ba\u8166\u4e2d\u767d\u8cea\u7684\u5fae\u74b0\u5883\u88ab\u6539\u8b8a\u4e86\uff0c\u9020\u6210\u98f2\u98df\u7fd2\u6163\u3001\u60c5\u7dd2\u8ddf\u8a8d\u77e5\u529f\u80fd\u90fd\u88ab\u4e00\u8d77\u6539\u8b8a\u3002<\/p>\n\n\n\n<p>\u800c\u4e14\u80f0\u5cf6\u7d20\u904e\u9ad8\u9084\u6703\u5f71\u97ff\u591a\u56ca\u5973\u5b69\u770b\u5230\u98df\u7269\u6642\u8166\u4e2d\u7684\u53cd\u61c9\uff0c\u9019\u6216\u8a31\u4e5f\u80fd\u8aaa\u660e\uff0c\u70ba\u4f55\u591a\u56ca\u5973\u5b69\u660e\u77e5\u9053\u8a72\u63a7\u5236\u98f2\u98df\uff0c\u537b\u6709\u6642\u5019\u6703\u9006\u5411\u64cd\u4f5c\uff0c\u6211\u5011\u771f\u7684\u4e0d\u8a72\u7528\u63a7\u5236\u529b\u4e0d\u8db3\u4e00\u53e5\u8a71\u4f86\u96a8\u4fbf\u4e0b\u5b9a\u8ad6\u54ea\uff01<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"5_%E4%BB%A3%E8%AC%9D%E9%AB%94%E5%AD%B8Metabolome_Changes\"><\/span><strong>5. \u4ee3\u8b1d\u9ad4\u5b78(Metabolome Changes)<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>&nbsp;\u4e00\u53e5\u8a71\u4f86\u89e3\u91cb\uff0c\u4ee3\u8b1d\u9ad4\u5b78 (metabolomics)\u662f\u7d93\u7531\u6e2c\u5b9a\u4ee3\u8b1d\u7269 (metabolites)\u4f86\u6e2c\u5b9a\u751f\u7269\u65b0\u9673\u4ee3\u8b1d\u7cfb\u7d71\u7684\u4e00\u9580\u6280\u8853\u3002\u5f88\u591a\u7814\u7a76\u90fd\u767c\u73fe\u591a\u56ca\u6027\u5375\u5de2\u6709\u5f88\u591a\u4e0d\u6b63\u5e38\u7684\u4ee3\u8b1d\u7269\uff0c\u5305\u542b\u7518\u6cb9\u78f7\u9178\u3001\u8102\u8cea\u3001\u81bd\u6c41\u9178 \u3001\u652f\u93c8\u6c28\u57fa\u9178\u548c\u795e\u7d93\u9170\u80fa(Ceramides)\u7b49\u7b49\u3002\u800c\u4e14\u9019\u4e9b\u7570\u5e38\u7684\u4ee3\u8b1d\u7269\u4e5f\u6703\u5728\u5375\u5de2\u8ddf\u6ffe\u6ce1\u6db2\u4e2d\u88ab\u767c\u73fe\u3002<\/p>\n\n\n\n<p>\u4e5f\u6709\u7814\u7a76\u767c\u73fe\u8aaa\uff0c\u4e0d\u6392\u5375\u7684\u591a\u56ca\u5973\u5b69\u65cf\u7fa4\u4e2d\uff0c\u85c9\u7531\u80f0\u5cf6\u7d20\u6240\u7522\u751f\u7684\u4e73\u9178(Lactate)\uff0c\u5728\u9ec3\u9ad4\u7684\u9846\u7c92\u9ec3\u9ad4\u7d30\u80de\u4e2d\u662f\u6709\u986f\u8457\u7684\u7570\u5e38\u7684\u3002\u9019\u4e9b\u7a2e\u7a2e\u7684\u8b49\u64da\u96d6\u7136\u9084\u6c92\u6709\u4e00\u500b\u5f88\u660e\u6717\u7684\u7b54\u6848\uff0c\u4e0d\u904e\u4e5f\u9593\u63a5\u8b49\u5be6\u591a\u56ca\u6027\u5375\u5de2\u7684\u4ee3\u8b1d\u7570\u5e38\uff0c\u662f\u78ba\u5be6\u5b58\u5728\u7684\u4e8b\u5be6\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%A4%9A%E5%9B%8A%E6%80%A7%E5%8D%B5%E5%B7%A2%E7%9A%84%E6%B2%BB%E7%99%82\"><\/span><strong>\u591a\u56ca\u6027\u5375\u5de2\u7684\u6cbb\u7642<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u6211\u5011\u5f9e\u4e94\u500b\u9762\u5411\u770b\u5b8c\u591a\u56ca\u6027\u5375\u5de2\u7684\u65b0\u767c\u5c55\u5f8c\uff0c\u5927\u5bb6\u6700\u6572\u7897\u597d\u5947\u7684\u4e00\u5b9a\u662f\u5230\u5e95\u6709\u6c92\u6709\u65b0\u7684\u6cbb\u7642\u963f? \u6240\u4ee5\uff0c\u63a5\u4e0b\u4f86\u6211\u5011\u5c31\u662f\u4f86\u770b\u770b\u662f\u5426\u6709\u65b0\u7684\u6cbb\u7642\u65b9\u6cd5\u5537\u3002<\/p>\n\n\n\n<p>\u5728\u8a0e\u8ad6\u6cbb\u7642\u9019\u584a\u7684\u6642\u5019\uff0c\u6211\u5011\u4e00\u5b9a\u8981\u6709\u4e00\u500b\u8a8d\u77e5\uff0c\u90a3\u5c31\u662f\u591a\u56ca\u662f\u4e00\u500b\u7121\u6cd5\u6cbb\u7652\uff0c\u4f46\u662f\u53ef\u4ee5\u6162\u6027\u63a7\u5236\u7684\u554f\u984c\u3002\u800c\u63a7\u5236\u7684\u7b2c\u4e00\u6b65\uff0c\u4e00\u5b9a\u5c31\u662f\u300c\u751f\u6d3b\u7fd2\u6163\u7684\u6539\u8b8a\u300d\uff0c\u5305\u542b\u50cf\u662f\u5730\u4e2d\u6d77\u98f2\u98df\u3001\u5fae\u91cf\u71df\u990a\u7d20\u7684\u88dc\u5145(\u8acb\u671f\u5f85\u6211\u672a\u4f86\u6703\u51fa\u7684\u591a\u56ca\u5973\u5b69\u4fdd\u5065\u54c1\u5927\u5168)\uff0c\u8ddf\u6bcf\u65e5\u5361\u8def\u91cc\u7684\u9650\u5236\u3002<\/p>\n\n\n\n<p>\u904b\u52d5\u4e5f\u662f\u4e00\u5b9a\u5fc5\u9808\u505a\u7684\u9805\u76ee\uff0c\u5f88\u591a\u4eba\u4ee5\u70ba\u904b\u52d5\u53ea\u662f\u70ba\u4e86\u6e1b\u80a5\uff0c\u7d55\u5c0d\u4e0d\u53ea\u5982\u6b64\u3002\u904b\u52d5\u662f\u91cd\u65b0\u96d5\u5851\u6211\u5011\u8eab\u9ad4\u7d44\u6210\u7684\u4e00\u9805\u4fee\u7df4\uff0c\u5305\u542b\u808c\u8089\u3001\u8102\u80aa\u7684\u6bd4\u4f8b\u8ddf\u5206\u5e03\u4f4d\u7f6e\u90fd\u6703\u6709\u6539\u8b8a\uff0c\u9019\u4e0d\u53ea\u662f\u589e\u52a0\u57fa\u790e\u4ee3\u8b1d\u9019\u9ebc\u55ae\u7d14\u3001\u9019\u4e5f\u78ba\u5be6\u6703\u8b93\u80f0\u5cf6\u7d20\u7684\u4ee3\u8b1d\u9032\u6b65\uff0c\u9032\u800c\u6539\u5584\u4ee5\u4e0a\u4e94\u5927\u9762\u5411\u5e36\u4f86\u7684\u4e0d\u826f\u5f71\u97ff\u3002<\/p>\n\n\n\n<p>\u4ee5\u85e5\u7269\u4f86\u8aaa\uff0c\u5c0d\u65bc\u6539\u5584\u4ee3\u8b1d\u6700\u5e38\u88ab\u4f7f\u7528\u7684\u5c31\u662fMetformin\uff0c\u4e00\u7a2e\u6e1b\u5c11\u809d\u81df\u7cd6\u8cea\u65b0\u751f\u3001\u589e\u52a0\u80f0\u5cf6\u7d20\u654f\u611f\u7684\u85e5\u7269\u3002\u4f46\u662f\u4e26\u4e0d\u662f\u6bcf\u500b\u591a\u56ca\u5973\u5b69\u90fd\u5c0dMetformin\u6709\u53cd\u61c9\u7684\uff0c\u6709\u7814\u7a76\u767c\u73fe\u8aaa\u5982\u679cMetformin\u53ef\u4ee5\u5408\u4f75\u808c\u9187(Inositol)\uff0c\u9664\u4e86\u53ef\u4ee5\u589e\u9032\u80f0\u5cf6\u7d20\u7684\u529f\u80fd\u5916\uff0c\u4e5f\u5c0d\u6539\u5584\u6708\u7d93\u9031\u671f\u6709\u5e6b\u52a9\u3002<\/p>\n\n\n\n<p>\u6b64\u5916\uff0c\u5c0d\u65bc\u6709\u80a5\u80d6\u554f\u984c\u7684\u591a\u56ca\u5973\u5b69\uff0c\u4e5f\u6709\u7814\u7a76\u767c\u73fe\u8aaa\u5728Metformin\u4e4b\u5916\u589e\u52a0GLP-1RA\uff0c\u4e5f\u5c31\u662f\u73fe\u5728\u5e02\u9762\u4e0a\u5f88\u7d05\u7684\u300c\u7626\u7626\u91dd\u300d\u7684\u76f8\u95dc\u85e5\u7269\uff0c\u53ef\u4ee5\u6e1b\u7de9\u591a\u56ca\u5973\u5b69\u9032\u5c55\u5230\u7cd6\u5c3f\u75c5\u7684\u6a5f\u6703\u3002<\/p>\n\n\n\n<p>\u4f46\u53ef\u60dc\u7684\u662f\uff0cMetformin\u96d6\u7136\u6709\u8af8\u591a\u597d\u8655\uff0c\u4f46\u5c0d\u65bc\u96c4\u6027\u7d20\u904e\u9ad8\u4ecd\u662f\u6c92\u6709\u5e6b\u52a9\uff0c\u4e14\u6709\u4e9b\u4eba\u6703\u6709\u5641\u5fc3\u3001\u5614\u5410\u7b49\u526f\u4f5c\u7528\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%A4%9A%E5%9B%8A%E6%B2%BB%E7%99%82%E4%B8%8A%E7%9A%84%E5%9B%B0%E5%A2%83\"><\/span>\u591a\u56ca\u6cbb\u7642\u4e0a\u7684\u56f0\u5883<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u6700\u5f8c\uff0c\u6211\u5011\u4f86\u63d0\u4e00\u4e0b\u591a\u56ca\u6cbb\u7642\u4e0a\u7684\u56f0\u5883\u3002<\/p>\n\n\n\n<p>\u6709\u9818\u904e\u6211\u591a\u56ca\u5206\u578b\u8868(<a href=\"https:\/\/drelephatshow.ck.page\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/drelephatshow.ck.page<\/a>)\u7684\u670b\u53cb\u4e00\u5b9a\u77e5\u9053\uff0c\u591a\u56ca\u7684\u5206\u985e\u81f3\u5c11\u6709\u5206\u4e09\u578b\uff0c\u800c\u5176\u4e2d\u4e0d\u540c\u985e\u578b\u5f62\u6210\u7684\u539f\u56e0\u9084\u6b63\u5728\u88ab\u7814\u7a76\u7576\u4e2d\u3002\u4f46\u6709\u4e00\u4ef6\u4e8b\u662f\u6211\u5011\u76ee\u524d\u4e0d\u80fd\u5ffd\u7565\u7684\uff0c\u90a3\u5c31\u662f\u591a\u56ca\u5973\u5b69\u7684\u4e0b\u4e00\u4ee3\u4e5f\u6bd4\u8f03\u5bb9\u6613\u6709\u4ee3\u8b1d\u6027\u554f\u984c\uff0c\u9019\u751a\u81f3\u53ef\u4ee5\u8ffd\u6eaf\u5230\u80da\u80ce\u65e9\u671f\u7684\u5f62\u6210\u4e2d\u3002<\/p>\n\n\n\n<p>\u8b1b\u4e00\u500b\u984c\u5916\u8a71\uff0c\u9019\u7a2e\u672c\u8eab\u75be\u75c5\u6703\u5f71\u97ff\u4e0b\u4e00\u4ee3\u7684\u7406\u8ad6\uff0c\u662f\u6e90\u81ea\u65bcDavid Barkers\u7b49\u4eba\uff0c\u4ed6\u5011\u767c\u73fe\u82e5\u662f\u5abd\u5abd\u672c\u8eab\u6709\u71df\u990a\u7f3a\u4e4f\u7684\u554f\u984c\uff0c\u4e0b\u4e00\u4ee3\u7684\u5b69\u5b50\u6bd4\u8f03\u5bb9\u6613\u6709\u80f0\u5cf6\u7d20\u5206\u6ccc\u7570\u5e38\u3001\u8461\u8404\u7cd6\u8ddf\u8102\u80aa\u4ee3\u8b1d\u7de9\u6162\u7684\u554f\u984c\uff0c\u4f46\u9019\u53ef\u80fd\u662f\u4ed6\u5011\u8981\u4fdd\u8b77\u81ea\u5df1\u7684\u4e00\u7a2e\u7b56\u7565\uff0c\u56e0\u70ba\u4ed6\u5011\u5728\u80da\u80ce\u7684\u74b0\u5883\u8b93\u4ed6\u5011\u4ee5\u70ba\u300c\u4ed6\u5011\u4e0d\u80fd\u6d6a\u8cbb\u4e00\u7d72\u4e00\u6beb\u7684\u80fd\u91cf\u300d\uff0c\u4f46\u6700\u5f8c\u53cd\u800c\u9020\u6210\u4ed6\u5011\u5bb9\u6613\u751f\u6210\u4ee3\u8b1d\u75c7\u5019\u7fa4\u7b49\u554f\u984c\u3002<\/p>\n\n\n\n<p class=\"has-ast-global-color-2-color has-text-color\">\u800c\u9019\u500b\u8ad6\u9ede\u5728\u591a\u56ca\u6027\u5375\u5de2\u4e2d\u4e5f\u9010\u6f38\u88ab\u8b49\u5be6(\u4e0b\u5716)\uff0c\u6709\u52d5\u7269\u5be6\u9a57\u767c\u73fe\uff0c\u5982\u679c\u5c0f\u5b69\u5728\u80da\u80ce\u6642\u671f\u5c31\u53d7\u5230\u5abd\u5abd\u96c4\u6027\u7d20\u904e\u9ad8\u6240\u5f71\u97ff\u3002<\/p>\n\n\n\n<p class=\"has-ast-global-color-2-color has-text-color\"><strong>\u6703\u9020\u6210\u8461\u8404\u7cd6\u4ee3\u8b1d\u7570\u5e38\u3001\u5167\u81df\u8102\u80aa\u5bb9\u6613\u7d2f\u7a4d\u7684\u72c0\u6cc1\uff0c\u8102\u80aa\u809d\u7684\u767c\u751f\u7387\u4e5f\u66f4\u9ad8\uff01\u5728\u82ac\u862d\u7684\u5be6\u9a57\u4e2d\u767c\u73fe\uff0c\u591a\u56ca\u7684\u5c0f\u5b69\u67091.58\u500d\u7684\u6a5f\u6703\u767c\u5c55\u5b69\u7ae5\u80a5\u80d6\u30012.06\u500d\u7684\u6a5f\u6703\u6703\u5728\u6210\u5e74\u671f\u6709\u7cd6\u5c3f\u75c5\u3002<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" src=\"https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/08\/image-1.png\" alt=\"\u591a\u56ca\u6027\u5375\u5de2\u7684\u60e1\u6027\u5faa\u74b0\" class=\"wp-image-3292\" style=\"object-fit:contain;width:600px;height:500px\" width=\"600\" height=\"500\"\/><\/figure>\n\n\n\n<p class=\"has-medium-font-size\"><strong>\u800c\u9019\u6a23\u7684\u7814\u7a76\u7d66\u6211\u5011\u4ec0\u9ebc\u555f\u793a?<\/strong><\/p>\n\n\n\n<p>\u90a3\u5c31\u662f\u7b49\u5230\u60f3\u61f7\u5b55\u7684\u6642\u5019\u518d\u958b\u59cb\u8abf\u990a\u8eab\u9ad4\uff0c\u662f\u7de9\u4e0d\u6fdf\u6025\u7684\u4e8b\u60c5\u3002Mintjens\u7b49\u4eba\u5c31\u63d0\u51fa\uff0c\u81f3\u5c11\u9700\u8981\u5728\u60f3\u8981\u61f7\u5b55\u524d\u516d\u500b\u6708\u5c31\u958b\u59cb\u505a\u51fa\u8abf\u6574\uff0c\u5305\u542b\u98f2\u98df\u8abf\u6574\u3001\u904b\u52d5\u3001\u85e5\u7269\u53ca\u4fdd\u5065\u54c1\u7684\u4ecb\u5165\u7b49\u3002<\/p>\n\n\n\n<p>\u800c\u672a\u4f86\u7684\u591a\u56ca\u6027\u5375\u5de2\u7684\u6cbb\u7642\uff0c\u6211\u500b\u4eba\u76f8\u4fe1\uff0c\u6703\u5728\u9664\u4e86\u6cbb\u7642\u80f0\u5cf6\u7d20\u963b\u6297\u3001\u96c4\u6027\u7d20\u904e\u9ad8\u4e4b\u5916\uff0c\u6703\u52a0\u5165\u66f4\u591a\u7684\u57fa\u56e0\u7be9\u6aa2\u8ddf\u57fa\u56e0\u6cbb\u7642\uff0c\u71df\u990a\u8abf\u7406\u4e5f\u6703\u662f\u6839\u64da\u4e0d\u540c\u7684\u591a\u56ca\u5f62\u614b\u505a\u51fa\u500b\u4eba\u5316\u7684\u6cbb\u7642\uff0c\u800c\u808c\u9187\u3001\u7dad\u4ed6\u547dD3\u751a\u81f3\u9b5a\u6cb9\u7b49\u90fd\u6703\u8b8a\u6210\u53ea\u662f\u57fa\u672c\u6b3e\u7684\u88dc\u5145\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%9F%A5%E9%81%93%E6%9B%B4%E5%A4%9A\"><\/span><strong>\u77e5\u9053\u66f4\u591a<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><a href=\"https:\/\/www.instagram.com\/elephantalkshow\/\" target=\"_blank\" rel=\"noopener\">\u8acb\u8ffd\u8e64\u6211\u7684IG<\/a><a href=\"\"><\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/lin.ee\/gL6PPc9\" target=\"_blank\" rel=\"noopener\">\u52a0\u5165\u6211\u7684\u5b98\u65b9Line(\u5167\u6709\u63a8\u85a6\u7684\u4fdd\u5065\u54c1)<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/www.facebook.com\/elephantalkshow\/\" target=\"_blank\" rel=\"noopener\">\u8ffd\u8e64\u6211\u7684FB<\/a><\/p>\n\n\n\n<p>\u52a0\u5165\u6211\u7684\u96fb\u5b50\u5831\u5537<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Reference\"><\/span><strong>Reference<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Yue Che \u2020, Jie Yu \u2020, Yu-Shan Li, Yu-Chen Zhu and Tao Tao. Polycystic Ovary Syndrome: Challenges and Possible Solutions<\/p>\n\n\n\n<p>Sun, Z.; Chang, H.M.;Wang, A.; Song, J.; Zhang, X.; Guo, J.; Leung, P.C.K.; Lian, F. Identification of potential metabolic biomarkers<\/p>\n\n\n\n<p>of polycystic ovary syndrome in follicular fluid by SWATH mass spectrometry. Reprod. Biol. Endocrinol. 2019, 17, 45<\/p>\n\n\n\n<p>Manti, M.; Fornes, R.; Pironti, G.; McCann Haworth, S.; Zhengbing, Z.; Benrick, A.; Carlstrom, M.; Andersson, D.; Stener-Victorin,<\/p>\n\n\n\n<p>E. Maternal androgen excess induces cardiac hypertrophy and left ventricular dysfunction in female mice offspring. Cardiovasc.<\/p>\n\n\n\n<p>Res. 2020, 116, 619\u2013632.<\/p>\n\n\n\n<p>Roland, A.V.; Nunemaker, C.S.; Keller, S.R.; Moenter, S.M. Prenatal androgen exposure programs metabolic dysfunction in female<\/p>\n\n\n\n<p>mice. J. Endocrinol. 2010, 207, 213\u2013223<\/p>\n\n\n\n<p>Barker, D.J. Developmental origins of adult health and disease. J. Epidemiol. Community Health 2004, 58, 114\u2013115<\/p>\n\n\n\n<p>Mintjens, S.; van Poppel, M.N.M.; Groen, H.; Hoek, A.; Mol, B.W.; Painter, R.C.; Gemke, R.; Roseboom, T.J. The Effects of a<\/p>\n\n\n\n<p>Preconception Lifestyle Intervention on Childhood Cardiometabolic Health-Follow-Up of a Randomized Controlled Trial. Cells<\/p>\n\n\n\n<p>2021, 11, 41<\/p>\n\n\n\n<p>Aburto-Hernandez, C.; Barrera, D.; Ortiz-Hernandez, R.; Espinoza-Simon, E.; Parra-Gamez, L.; Gonzalez, J.; Escobar, M.L.;<\/p>\n\n\n\n<p>Vazquez-Nin, G.H.; Echeverria-Martinez, O.; Torres-Ramirez, N. Impaired Carbohydrate Metabolism and Excess of Lipid<\/p>\n\n\n\n<p>Accumulation in Offspring of Hyperandrogenic Mice. Metabolites 2022, 12, 1182<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8eab\u70ba\u4e00\u500b\u5728\u5973\u6027\u4e2d\u76db\u884c\u7387\u9ad8\u90546-21%\u7684\u75be\u75c5\uff0c\u6bcf\u5e74\u81f3\u5c11\u90fd\u6709\u8d85\u904e150\u842c\u500b\u65b0\u8a3a\u65b7\u51fa\u4f86\u7684\u591a\u56ca\u60a3\u8005\uff0c\u800c\u4e14\u65b0\u7684\u8a3a\u65b7\u6709\u9010\u6f38 &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"\" href=\"https:\/\/elephantalkshow.com\/%e6%96%b0%e7%9a%84%e5%a4%9a%e5%9b%8a%e6%82%a3%e8%80%85%e4%ba%ba%e6%95%b8%e7%af%80%e7%af%80%e4%b8%8a%e5%8d%87%e4%b8%ad%ef%bc%8c%e8%80%8c%e6%88%91%e5%80%91%e6%96%b0%e7%9a%84%e5%b1%95%e6%9c%9b%e6%98%af\/\"> <span class=\"screen-reader-text\">\u65b0\u7684\u591a\u56ca\u60a3\u8005\u4eba\u6578\u7bc0\u7bc0\u4e0a\u5347\u4e2d\uff0c\u800c\u6211\u5011\u65b0\u7684\u5c55\u671b\u662f?<\/span> \u95b1\u8b80\u5168\u6587 \u00bb<\/a><\/p>\n","protected":false},"author":2,"featured_media":3293,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[7],"tags":[25,16,24,20,49,83],"_links":{"self":[{"href":"https:\/\/elephantalkshow.com\/wp-json\/wp\/v2\/posts\/3290"}],"collection":[{"href":"https:\/\/elephantalkshow.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/elephantalkshow.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/elephantalkshow.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/elephantalkshow.com\/wp-json\/wp\/v2\/comments?post=3290"}],"version-history":[{"count":1,"href":"https:\/\/elephantalkshow.com\/wp-json\/wp\/v2\/posts\/3290\/revisions"}],"predecessor-version":[{"id":3294,"href":"https:\/\/elephantalkshow.com\/wp-json\/wp\/v2\/posts\/3290\/revisions\/3294"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/elephantalkshow.com\/wp-json\/wp\/v2\/media\/3293"}],"wp:attachment":[{"href":"https:\/\/elephantalkshow.com\/wp-json\/wp\/v2\/media?parent=3290"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/elephantalkshow.com\/wp-json\/wp\/v2\/categories?post=3290"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/elephantalkshow.com\/wp-json\/wp\/v2\/tags?post=3290"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}