{"id":1423,"date":"2023-01-13T10:45:19","date_gmt":"2023-01-13T02:45:19","guid":{"rendered":"https:\/\/elephantalkshow.com\/?p=1423"},"modified":"2023-02-03T14:10:15","modified_gmt":"2023-02-03T06:10:15","slug":"parpi%e6%bc%94%e8%ac%9b-%e5%8d%b5%e5%b7%a2%e7%99%8c%e6%b2%bb%e7%99%82","status":"publish","type":"post","link":"https:\/\/elephantalkshow.com\/parpi%e6%bc%94%e8%ac%9b-%e5%8d%b5%e5%b7%a2%e7%99%8c%e6%b2%bb%e7%99%82\/","title":{"rendered":"PARPi\u6f14\u8b1b-\u5375\u5de2\u764c\u6cbb\u7642"},"content":{"rendered":"\n<p>\u4eca\u65e9\u807d\u4e86\u53f0\u5927\u5a66\u7522\u79d1\u9b4f\u6559\u6388<\/p>\n\n\n\n<p>\u95dc\u65bc\u5375\u5de2\u764c\u6a19\u9776\u85e5\u7269\u7684\u6cbb\u7642<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"554\" height=\"312\" src=\"https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/01\/\u5716\u724723.jpg\" alt=\"\" class=\"wp-image-1429\" srcset=\"https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/01\/\u5716\u724723.jpg 554w, https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/01\/\u5716\u724723-300x169.jpg 300w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/><\/figure>\n\n\n\n<p>\u5728\u6cbb\u7642\u5375\u5de2\u764c\u65b9\u9762\u9019\u5e7e\u5e74\u6709\u4e00\u7a2e\u85e5\u7269\u53eb\u505aPARP\u6291\u5236\u5291<\/p>\n\n\n\n<p>PARP\u70baPoly (ADP-ribose) polymerase\u4e4b\u610f<\/p>\n\n\n\n<p>\u6240\u4ee5PARP\u6291\u5236\u5291\u662f\u805aADP\u6838\u7cd6\u805a\u5408\u9176\u7684\u6291\u5236\u5291<\/p>\n\n\n\n<p>\u6b64\u85e5\u7269\u91dd\u5c0d\u5375\u5de2\u764c\u7576\u4e2d\u6709BRCA\u57fa\u56e0\u7a81\u8b8a<\/p>\n\n\n\n<p>\u6216\u8005\u662fHRD(\u540c\u6e90\u91cd\u7d44\u4fee\u5fa9\u7f3a\u5931)\u7684\u65cf\u7fa4<\/p>\n\n\n\n<p>\u6709\u7279\u5225\u597d\u7684\u7642\u6548(\u57161)<\/p>\n\n\n\n<p>\u539f\u7406\u662f\u4ec0\u9ebc\u5462?<\/p>\n\n\n\n<p>\u4e0d\u7ba1\u662f\u55ae\u80a1\u6216\u96d9\u80a1\u7684DNA\u51fa\u73fe\u640d\u58de\u4e4b\u5f8c<\/p>\n\n\n\n<p>\u6211\u5011\u7d30\u80de\u672c\u8eab\u90fd\u6709\u81ea\u6211\u4fee\u5fa9\u7684\u80fd\u529b<\/p>\n\n\n\n<p>\u5176\u4e2d\u81ea\u6211\u4fee\u5fa9\u5206\u70ba<\/p>\n\n\n\n<ol type=\"1\">\n<li>\u540c\u6e90\u91cd\u7d44(Homologous recombination , HR)\u7684\u4fee\u5fa9<\/li>\n\n\n\n<li>\u975e\u540c\u6e90\u67d3\u8272\u9ad4\u9ecf\u5408(non-homologous end-joining, NHEJ)\u7684\u4fee\u5fa9<\/li>\n<\/ol>\n\n\n\n<p>\u5176\u4e2d\u5f8c\u8005\u56e0\u70ba\u6c92\u6709\u540c\u6e90\u5e8f\u5217\u7684\u5f15\u5c0e\uff0c\u8f03\u5bb9\u6613\u7522\u751f\u932f\u8aa4<\/p>\n\n\n\n<p>\u800c\u524d\u8005\u8f03\u80fd\u7cbe\u7d30\u7684\u4fee\u88dc\u96d9\u80a1DNA\u7684\u932f\u8aa4<\/p>\n\n\n\n<p>\u800cPARP\u8ddfBRCA\u5169\u8005\u90fd\u662f\u57fa\u56e0\u4fee\u5fa9\u7684\u65b9\u5f0f<\/p>\n\n\n\n<p>PARP\u662f\u55ae\u80a1DNA(Single-strand DNA)\u7684\u4fee\u5fa9<\/p>\n\n\n\n<p>BRCA\u662f\u96d9\u80a1DNA(Double-strand DNA)\u7684\u4fee\u5fa9<\/p>\n\n\n\n<p>\u7576\u4e00\u500b\u4eba\u6709BRCA\u7684\u7a81\u8b8a\u6642\uff0c\u4ee3\u8868\u5176\u816b\u7624\u5931\u53bb\u4e86\u5176\u4e2d\u4e00\u7a2e\u4fee\u5fa9\u65b9\u5f0f<\/p>\n\n\n\n<p>\u82e5\u9019\u6642\u5019\u6211\u5011\u518d\u6253\u65b7\u4ed6\u7684PARP\u4fee\u5fa9\u65b9\u5f0f<\/p>\n\n\n\n<p>\u5247\u816b\u7624\u5c31\u6703\u56e0\u70baDNA\u7684\u640d\u50b7\u4e0d\u65b7\u7684\u7d2f\u7a4d\uff0c\u800c\u7121\u6cd5\u5b58\u6d3b<\/p>\n\n\n\n<p>\u9019\u5c31\u662f\u8fd1\u5e74\u975e\u5e38\u592f\u7684PARP\u6291\u5236\u5291\u7684\u539f\u7406\u3002<\/p>\n\n\n\n<p>\u4f46\u5176\u5be6\u4eca\u65e9\u7684\u6f14\u8b1b\u63d0\u5230\u5728\u7528\u6b64\u85e5\u7269\u6301\u7e8c\u6cbb\u7642\u4e4b\u5f8c<\/p>\n\n\n\n<p>\u7684\u7b2c\u4e8c\u5e74\u5c31\u53ea\u526974%\u7684\u4eba\u6709\u6548<\/p>\n\n\n\n<p>\u70ba\u4f55\u670926%\u7684\u4eba\u6703\u5c0dPARP\u6291\u5236\u5291\u7684\u7642\u6548\u4e0d\u4f73\u5462(Resistance)<\/p>\n\n\n\n<p>\u70ba\u4ec0\u9ebc\u5462? \u5176\u5be6\u539f\u56e0\u5f88\u591a<\/p>\n\n\n\n<p>\u6709\u53ef\u80fd\u662fPAR glycohydrolase(\u7cd6\u6c34\u89e3\u9176)\u7684\u7f3a\u5931<\/p>\n\n\n\n<p>\u8b93PAR\u7684\u7d30\u80de\u4fee\u5fa9\u8a0a\u865f\u80fd\u5920\u91cd\u65b0\u958b\u59cb\u9032\u884c<\/p>\n\n\n\n<p>\u8b93\u4e3b\u8981\u4f9d\u8cf4BRCA2\u57fa\u56e0\u4fee\u5fa9\u7684\u816b\u7624<\/p>\n\n\n\n<p>\u5c0dPARP\u6291\u5236\u5291\u7121\u6548(\u5716\u4e8c)<\/p>\n\n\n\n<p>\u9664\u6b64\u4e4b\u5916<\/p>\n\n\n\n<p>\u975e\u540c\u6e90\u6027\u672b\u7aef\u63a5\u5408\u4e5f\u626e\u6f14\u4e00\u500b\u91cd\u8981\u7684\u8173\u8272<\/p>\n\n\n\n<p>\u975e\u540c\u6e90\u6027\u7684\u672b\u7aef\u63a5\u5408\uff0c\u662f\u4e00\u7a2e\u4fee\u5fa9\u96d9\u80a1DNA\u65b7\u88c2\u7684\u65b9\u6cd5<\/p>\n\n\n\n<p>\u4e4b\u6240\u4ee5\u662f\u975e\u540c\u6e90\u6027<\/p>\n\n\n\n<p>\u662f\u56e0\u70ba\u65b7\u88c2\u7684\u5169\u6bb5\u662f\u88ab\u76f4\u63a5\u63a5\u4e0a\uff0c\u800c\u975e\u4f7f\u7528\u4e86\u4e00\u500b\u540c\u6e90\u7684\u6a21\u677f(\u57164)<\/p>\n\n\n\n<p>PARP\u6291\u5236\u5291\u6548\u679c\u4e0d\u4f73\u7684\u53e6\u4e00\u500b\u539f\u56e0<\/p>\n\n\n\n<p>\u4e5f\u53ef\u80fd\u662f\u975e\u540c\u6e90\u6027\u672b\u7aef\u63a5\u5408\u7684\u4fc3\u9032\u56e0\u5b50BP531\u7684\u5b58\u5728<\/p>\n\n\n\n<p>\u8b93\u816b\u7624\u7684\u5fae\u74b0\u5883(Microenvironment)\u6539\u8b8a<\/p>\n\n\n\n<p>\u8b93PARP\u6291\u5236\u5291\u7684\u80fd\u529b\u4e0b\u964d\u3002(\u57165)<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"893\" height=\"1024\" src=\"https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/01\/\u5716\u724724-893x1024.jpg\" alt=\"\" class=\"wp-image-1424\" srcset=\"https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/01\/\u5716\u724724-893x1024.jpg 893w, https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/01\/\u5716\u724724-600x688.jpg 600w, https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/01\/\u5716\u724724-262x300.jpg 262w, https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/01\/\u5716\u724724-768x881.jpg 768w, https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/01\/\u5716\u724724.jpg 1269w\" sizes=\"(max-width: 893px) 100vw, 893px\" \/><\/figure>\n\n\n\n<p>\u57162:\u57282018\u5e74\u975e\u5e38\u6709\u540d\u7684SOLO1 trial\u4e2d\u63d0\u5230\uff0cPARP\u6291\u5236\u5291\u91dd\u5c0d\u6709BRCA1\/2\u7a81\u8b8a\u7684\u5375\u5de2\u764c\u60a3\u8005\uff0c\u5728\u4e09\u5e74\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f(PFS)\u6bd4\u8f03\u4e2d\uff0c\u6709\u7528\u85e5\u7684\u662f60%\uff1b\u6c92\u6709\u7528\u85e5\u7684\u662f27%\u3002\u85e5\u7269\u63a7\u5236\u5375\u5de2\u764c\u7684\u6548\u679c\u986f\u8457\u3002<\/p>\n\n\n\n<p>(&nbsp;Eastern Cooperative Oncology Group performance status of 0\u20131 and with&nbsp;<em>BRCA<\/em>-mutated, newly diagnosed, advanced, high-grade serous or endometrioid ovarian cancer with a complete or partial clinical response after platinum-based chemotherapy)<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"515\" height=\"516\" src=\"https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/01\/\u5716\u724725.png\" alt=\"\" class=\"wp-image-1425\" srcset=\"https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/01\/\u5716\u724725.png 515w, https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/01\/\u5716\u724725-300x300.png 300w, https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/01\/\u5716\u724725-100x100.png 100w, https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/01\/\u5716\u724725-150x150.png 150w\" sizes=\"(max-width: 515px) 100vw, 515px\" \/><\/figure>\n\n\n\n<p>\u57163:\u4f86\u81eaSelective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality\uff0c\u8aaa\u660e\u816b\u7624\u7d30\u80de\u56e0\u70baPARG\u7684\u7f3a\u5931\uff0c\u8b93PARP1\u7684\u8a0a\u865f\u91cd\u65b0\u6d3b\u5316\uff0c\u800c\u5c0dPARP\u6291\u5236\u5291\u7121\u6548<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"554\" height=\"253\" src=\"https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/01\/\u5716\u724726.png\" alt=\"\" class=\"wp-image-1426\" srcset=\"https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/01\/\u5716\u724726.png 554w, https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/01\/\u5716\u724726-300x137.png 300w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/><\/figure>\n\n\n\n<p>\u57164: NHEJ:\u975e\u540c\u6e90\u6027\u7684\u672b\u7aef\u63a5\u5408\uff0c\u662f\u4e00\u7a2e\u4fee\u5fa9\u96d9\u80a1DNA\u65b7\u88c2\u7684\u65b9\u6cd5\u3002\u4e4b\u6240\u4ee5\u662f\u975e\u540c\u6e90\u6027\uff0c\u662f\u56e0\u70ba\u65b7\u88c2\u7684\u5169\u6bb5\u662f\u88ab\u76f4\u63a5\u63a5\u4e0a\uff0c\u800c\u975e\u4f7f\u7528\u4e86\u4e00\u500b\u540c\u6e90\u7684\u6a21\u677f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"554\" height=\"304\" src=\"https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/01\/\u5716\u724727.png\" alt=\"\" class=\"wp-image-1427\" srcset=\"https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/01\/\u5716\u724727.png 554w, https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/01\/\u5716\u724727-300x165.png 300w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/><\/figure>\n\n\n\n<p>\u57165:\u56e0\u70ba\u975e\u540c\u6e90\u6027\u7684\u672b\u7aef\u63a5\u5408\u4fc3\u9032\u56e0\u5b50BP531\u7684\u5b58\u5728\uff0c\u8b93\u816b\u7624\u7d30\u80de<\/p>\n\n\n\n<p>\u7684\u5fae\u74b0\u5883\u767c\u751f\u6539\u8b8a\uff0c\u4e5f\u8b93\u816b\u7624\u7d30\u80de\u5f97\u4ee5\u91cd\u65b0\u4fee\u5fa9\uff0c\u4f7f\u5f97PARP\u6291\u5236\u5291\u7684\u6548\u679c\u4e0b\u964d\u3002<\/p>\n\n\n\n<p>\u9664\u4e86\u5a66\u79d1\u764c\u75c7\u6cbb\u7642\u4e4b\u5916<\/p>\n\n\n\n<p>\u5176\u5be6\u6211\u4e3b\u8981\u7684\u611f\u60f3\u53cd\u800c\u662f<\/p>\n\n\n\n<p>\u5728\u91ab\u85e5\u9019\u4e00\u584a\u91ab\u5e2b\u7684\u81e8\u5e8a\u5de5\u4f5c\u7684\u78ba\u975e\u5e38\u91cd\u8981<\/p>\n\n\n\n<p>\u4f46\u5f88\u591a\u6700\u65b0\u7684\u6cbb\u7642\u8ddf\u85e5\u7269\u958b\u767c<\/p>\n\n\n\n<p>\u5176\u5be6\u53cd\u800c\u662f\u5145\u6eff\u8cc7\u6e90\u7684\u85e5\u5ee0\u4f54\u4e86\u975e\u5e38\u5927\u7684\u529f\u52de<\/p>\n\n\n\n<p>\u50cf\u5728\u201d\u7834\u89e3\u57fa\u56e0\u78bc\u7684\u4eba\u201d\u66f8\u4e2d\u7684\u4e3b\u89d2<\/p>\n\n\n\n<p>\u73cd\u59ae\u4f5b(Jennifer Anne Doudna)\u662f2020\u5e74\u7684\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b<\/p>\n\n\n\n<p>\u4e5f\u662f\u89e3\u958b\u57fa\u56e0\u7de8\u8f2fCRISPER\u6280\u8853\u7684\u9818\u822a\u4eba\u4e4b\u4e00(\u57166)<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"554\" height=\"311\" src=\"https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/01\/\u5716\u724728.png\" alt=\"\" class=\"wp-image-1428\" srcset=\"https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/01\/\u5716\u724728.png 554w, https:\/\/elephantalkshow.com\/wp-content\/uploads\/2023\/01\/\u5716\u724728-300x168.png 300w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/><\/figure>\n\n\n\n<p>\u57166 : 2020\u5e74\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u73cd\u59ae\u4f5b.\u9053\u7d0d(Jennifer Anne Doudna)<\/p>\n\n\n\n<p>\u88e1\u9762\u63d0\u53ca\u5f88\u591a\u5979\u7684\u5718\u968a\u8ddf\u540c\u696d<\/p>\n\n\n\n<p>\u5728\u57fa\u56e0\u7de8\u8f2f\u9019\u584a\u6280\u8853\u4e0a\u4e92\u76f8\u7af6\u722d\u3001\u8d85\u8eca\u7684\u6545\u4e8b<\/p>\n\n\n\n<p>\u800c\u6700\u5f8c\u5f88\u611f\u4eba\u7684\u662f\uff0c\u7576Covid-19\u75ab\u60c5\u7206\u767c\u6642<\/p>\n\n\n\n<p>\u4ed6\u5011\u53cd\u800c\u7acb\u5373\u8ddf\u539f\u672c\u662f\u7af6\u722d\u8005\u7684\u5c0d\u624b<\/p>\n\n\n\n<p>\u4e92\u76f8\u4ea4\u6d41\u8cc7\u8a0a\u4f86\u4e00\u540c\u958b\u767c\u75ab\u82d7<\/p>\n\n\n\n<p>\u6211\u8a8d\u70ba\u9019\u662f\u9019\u5e7e\u5e74<\/p>\n\n\n\n<p>\u826f\u6027\u7af6\u722d\u5171\u5275\u4f73\u7e3e\u7684\u6700\u4f73\u5178\u7bc4\u4e4b\u4e00<\/p>\n\n\n\n<p>\u66f8\u4e2d\u4e5f\u6709\u8b1b\u5230AZ\u85e5\u5ee0(AstraZenace)<\/p>\n\n\n\n<p>\u5176\u5be6\u5728\u514d\u75ab\u3001\u764c\u75c7\u3001\u57fa\u56e0\u6aa2\u6e2c\u8ddf\u7de8\u8f2f\u9019\u584a<\/p>\n\n\n\n<p>\u90fd\u6295\u6ce8\u4e86\u975e\u5e38\u5927\u91cf\u7684\u8cc7\u6e90\u5728\u7814\u7a76<\/p>\n\n\n\n<p>\u66f4\u4e0d\u7528\u8aaa\u4eca\u5e742022\u5e7410\u6708AZ\u85e5\u5ee0<\/p>\n\n\n\n<p>\u9084\u8cb7\u4e0b\u4e86LogicBio\u9019\u500b\u57fa\u56e0\u6cbb\u7642\u516c\u53f8<\/p>\n\n\n\n<p>\u96d6\u7136\u958b\u767c\u75ab\u82d7\u5f88\u4e86\u4e0d\u8d77<\/p>\n\n\n\n<p>\u4f46AZ\u85e5\u5ee0\u7d55\u975e\u53ea\u662f\u505a\u958b\u767c\u75ab\u82d7\u800c\u5df2<\/p>\n\n\n\n<p>\u9664\u6b64\u4e4b\u5916\uff0c\u9019\u5169\u5e74\u7684\u75ab\u82d7\u80fd\u5920\u958b\u767c\u795e\u901f<\/p>\n\n\n\n<p>\u4e5f\u662f\u4ef0\u8cf4\u65bc\u5404\u9805\u6280\u8853\u7684\u6c34\u5230\u6e20\u6210<\/p>\n\n\n\n<p>\u5728\u672a\u4f86\uff0c\u57fa\u56e0\u6aa2\u6e2c\u7d55\u5c0d\u662f\u5065\u5eb7\u6aa2\u67e5\u7684\u4e3b\u8981\u9805\u76ee\u4e4b\u4e00<\/p>\n\n\n\n<p>\u8fd1\u671f\u6211\u4e5f\u5beb\u4e86\u4e00\u7bc7\u95dc\u65bcBRCA\u57fa\u56e0\u7684\u6587\u7ae0<\/p>\n\n\n\n<p>\u656c\u8acb\u5927\u5bb6\u671f\u5f85\u56c9!<\/p>\n\n\n\n<p>1.Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence Maintenance Olaparib in Patients with Newly Diagnosed Advanced Ovarian Cancer<\/p>\n\n\n\n<p>2.Maintenance olaparib for patients with newly diagnosed advanced ovarian cancer and a BRCA mutation (SOLO1\/GOG 3004): 5-year follow-up of a randomised, double-blind, placebo-controlled, phase 3 trial<\/p>\n\n\n\n<p>3.PARP inhibitor resistance in breast and gynecological cancer: Resistance mechanisms and combination therapy strategies<\/p>\n\n\n\n<p>4.Biomarkers beyond BRCA: promising combinatorial treatment strategies in overcoming resistance to PARP inhibitors<\/p>\n\n\n\n<p>5.\u764c\u75c7\u6cbb\u7642\u7684\u65b0\u601d\u7dad\uff0d \u5408\u6210\u81f4\u6b7b(Synthetic Lethality)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4eca\u65e9\u807d\u4e86\u53f0\u5927\u5a66\u7522\u79d1\u9b4f\u6559\u6388 \u95dc\u65bc\u5375\u5de2\u764c\u6a19\u9776\u85e5\u7269\u7684\u6cbb\u7642 \u5728\u6cbb\u7642\u5375\u5de2\u764c\u65b9\u9762\u9019\u5e7e\u5e74\u6709\u4e00\u7a2e\u85e5\u7269\u53eb\u505aPARP\u6291\u5236\u5291 PAR &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"\" href=\"https:\/\/elephantalkshow.com\/parpi%e6%bc%94%e8%ac%9b-%e5%8d%b5%e5%b7%a2%e7%99%8c%e6%b2%bb%e7%99%82\/\"> <span class=\"screen-reader-text\">PARPi\u6f14\u8b1b-\u5375\u5de2\u764c\u6cbb\u7642<\/span> \u95b1\u8b80\u5168\u6587 \u00bb<\/a><\/p>\n","protected":false},"author":2,"featured_media":1429,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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